Uric Acid Level as Predictor Preeclampsia in Pregnant Woman at Working Area of Public Health Centers in Kendari City, Southeast Sulawesi Province

Aswita, Aswita and Arsulfa, Arsulfa and Asi, Melania and Nurmiaty, Nurmiaty (2018) Uric Acid Level as Predictor Preeclampsia in Pregnant Woman at Working Area of Public Health Centers in Kendari City, Southeast Sulawesi Province. International Journal of Sciences : Basic and Applied Research (IJSBAR), 38 (2). pp. 237-246. ISSN 2307-4531

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Abstract

Preeclampsia is a common problem that occurs in pregnant women causing morbidity and mortality of mothers and babies to rise around the world. Studies have shown that in normotensive pregnancy, serum uric acid levels will begin to increase before the onset of symptoms of hypertension and proteinuria. This study aimed to determine differences in uric acid levels in healthy pregnant women and preeclampsia, as a predictor of preeclampsia events in the working area of Public Health Center in City of Kendari, Southeast Sulawesi Province. This research was an observational study using case-control study design. The sample of this study were pregnant women with gestational age above 20 weeks, divided into two groups, the case group consisting of pregnant women who experienced preeclampsia and the control group composed of pregnant women who did not experience preeclampsia. The total sample was 60 people. Data were analyzed using ROC, Chi-Square, Odds Ratio (OR) and Mann Whitney test. The value of cut-off point of the uric acid level of preeclampsia was ≥6,2 mg/dl. The levels of uric acid in the preeclampsia group were higher than in the non-preeclampsia group. Pregnant women who had uric acid levels ≥ 6, 2 mg/dl risk 13 times experienced preeclampsia. The result showed, the median value of uric acid level in preeclampsia group, was 7.39 mg/dl. The median value of uric acid levels in the preeclampsia group was 4.94 with a value (p = 0.000), meaning that there was a difference in uric acid levels between the preeclampsia group and the non-preeclampsia group. This research concludes that uric acid levels in the preeclampsia group were higher than those without preeclampsia. Pregnant women who have high uric acid levels risk 13 times experiencing preeclampsia.

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